Inferential modeling of 3D chromatin structure
نویسندگان
چکیده
منابع مشابه
Inferential modeling of 3D chromatin structure
For eukaryotic cells, the biological processes involving regulatory DNA elements play an important role in cell cycle. Understanding 3D spatial arrangements of chromosomes and revealing long-range chromatin interactions are critical to decipher these biological processes. In recent years, chromosome conformation capture (3C) related techniques have been developed to measure the interaction freq...
متن کاملInferential structure determination.
Macromolecular structures calculated from nuclear magnetic resonance data are not fully determined by experimental data but depend on subjective choices in data treatment and parameter settings. This makes it difficult to objectively judge the precision of the structures. We used Bayesian inference to derive a probability distribution that represents the unknown structure and its precision. Thi...
متن کاملLinguistic Structure and Inferential Communication
The replacement of code theories of communication by inferential theories has implications for the study of linguistic meaning. This paper surveys some of these implications and outlines an inferential theory – relevance theory – with which semantic analyses of context-dependent expressions, polysemous and ambiguous expressions, and non-truth-conditional expressions (e.g. mood indicators, disco...
متن کامل3D chromatin structure estimation through a constraint-enhanced score function
Based on experimental techniques of the type Chromosome Conformation Capture (3c), several methods have been proposed in the literature to estimate the structure of the nuclear dna in homogeneous populations of cells. Many of these methods transform contact frequencies into Euclidean distances between pairs of chromatin fragments, and then reconstruct the structure by solving a distance-to-geom...
متن کاملChromatin assortativity: integrating epigenomic data and 3D genomic structure
Background The field of 3D chromatin interaction mapping is changing our point of view on the genome, paving the way for new insights into its organization. Network analysis is a natural and powerful way of modelling chromatin interactions. Assortativity is a network property that has allowed social scientists to identify factors that affect how people establish social ties. We propose a new ap...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2015
ISSN: 1362-4962,0305-1048
DOI: 10.1093/nar/gkv100